> I mean I just don't see how you get to this opinion after any real review of the evidence.
Graybeard here: took me a while to get it, but, usually these are chances to elucidate what is obvious to you :)* ex. I don't really know what you mean. What does the California state government look like if rich techies had even more influence? I can construct a facile version (lower taxes**) but assuredly you mean more than that to be taken so aback.
* Good Atlas Shrugged quote on this: "Contradictions do not exist. Whenever you think that you are facing a contradiction, check [ED: or share, if you've moseyed yourself into a discussion] your premises."
** It's not 100% clear politicians steered by California techies would lower taxes ad infinitum.
I'm genuinely curious about your position, it's interesting.
But I can't figure it out what it'd look like in practice, might be hangover, might be I need more caffeine, whatever it is, it's on me. Don't read following as "you're saying X and thats silly!"
(A) Are consumption rates in general unsustainable?
(B) If (A) is no, are consumption rates of specific items unsustainable? For example, is the legislation you're thinking of like the deprecation of plastic bags for paper? Or something that covers a much wider amount of consumption?
(C) If (A) is "yes" or (B) is "more global", at huge scales like an economy, legislating quotas or rationing or anything at all, in practice pushes activity onto black markets.
If the concern is changing individual behavior, and individual behavior isn't changing on it's own sufficiently, what sort of legislation would change it?
So the idea of reducing consumption is misleading, the real solution is to reduce consumption (via the law forcing quotas on manufacturers and rationing on consumers)
I am bored to tears by this and it is simultaneously heart-breaking. My MD friend wasted $100K on MicroStrategy, ignoring my advice when he asked for it a couple months ago, and he's like "It's fine I'm not 65." and then proceeded to explain he absolutely should hold it because Trump will add it to Bitcoin strategic reserve.
Been following the market for 30 years and I've never seen loss per share > $10. They lost $42/share. Didn't make a dent in our conversation, I think he just ignored it twice.
Hims offered semaglutide for $99/month. That’s a 90% discount on unsubsidized consumer prices for injectable semaglutide. I also don’t see any evidence that they sold a placebo, but I’m just catching up now, perhaps I missed where they’re selling something with a different active ingredient which does not work.
I've since read TFA, as well as many other articles, official correspondence, and case law around the issue. I understand that without the additional ingredients of SNAC/sodium caprate/sodium caprylate, the bioavailability is probably too low to have a clinical effect at oral doses <15mg/day.
I read the actual FDA referral to the DOJ. They don't mention anything about any of what this article touches on. It's not clear that the referral makes correct claims about anything illegal going on. In statements, the FDA says that compounding pharmacies "cannot state compounded drugs use the same active ingredient as the FDA-approved drugs". That's a very brand-new interpretation of rules, and might not stand up to judicial scrutiny. In the context of "shouldn't investors have known that Hims business model is illegal??" -- it makes sense that investors couldn't have known ahead of time that the FDA would claim this.
i haven't read the article. is the question, can hims ship a clone of 25mg oral wegovy? yes, it can.
> ... at oral doses <15mg/day.
well it's not a clone of rybelsus, it's a clone of wegovy 25mg. so i suppose it will be bioavailable at 25mg.
> That's a very brand-new interpretation of rules
this is true. Tidmarsh, the whole Novo Nordisk deal with Trump, it's now about, well we'll do the patent enforcement we didn't want to do before. The simple fact of the matter is, these are lifestyle products, so it's not so black and white if they ought to have the same patent and payment protections as typical therapeutics.
> well it's not a clone of rybelsus, it's a clone of wegovy 25mg. so i suppose it will be bioavailable at 25mg.
No. RTFA. Feed it into an LLM with the first thought off the top of your head. Skim it quick. Whatever. (tl;dr: the clone skips the ingredient that makes the contents bioavailable)
i have a feeling that what actually happened is that absence of the ingredient in the text that the article is talking about is a documentation error, and that's why the FDA makes no mention about it at all (as you discovered). i think the thing that is getting shipped has the ingredient and this is a nothingburger.
indeed, the only evidence that the clone is missing the ingredients is the guy read a Reuters article about it, and asked the chatbot (presumably) to do research. the clones in this sector are pretty faithful. i'm going to chalk it up to, "declined to elaborate" doesn't mean, as the author insinuates, that Hims has a bad clone, i think they just didn't answer the question and there's nothing more to this.
this is coming from my place as knowing a lot about this sector and the simple fact of the matter is, they just make a clone and they do it faithfully.
“What’s more likely is they’re sitting on an unknown breakthrough that took pharmaceutical companies billions and years and just launched.” - you sure you read it this time?
It's not fast enough to be realtime, though you could do a more advanced UI and a ring buffer and have it as you describe. (ex. I do this with Whisper in Flutter, and also inference GGUFs in llama.cpp via Dart)
This isn't even close to realtime on M4 Max. Whisper's ~realtime on any device post-2022 with an ONNX implementation. The extra inference cost isn't worth the WER decrease on consumer hardware, or at least, wouldn't be worth the time implementing.
Flash memory (quantum tunneling), lasers (stimulated emission), transistors (band theory), MRI machines (nuclear spin), GPS (atomic transition), LED's (band gap), digital cameras (photoelectric effect), ...the list does, in fact, go on, and on, and on.
After some performance improvements, it is realtime on my DGX Spark with an RTF of .416 -- now getting ~19.5 tokens per second. Check it out, see if it's better for you.
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