this logic (barely) works for blogs. if your game is an aquarium game, it doesn't mean that your users are only interested in aquarium cleaning products.
yeah but the category "plays games" is too broad, rivaled by "reads blogs". And after the users have seen enough of gaming ads (and not responded) they are offeered the bottom of the barrel: russian brides (true story).
If we are going to go down the road of doing increasingly detailed ad customization as publishers, we will have come full circle to reinventing targeted ads by another name.