Yes, I have been using it for the bulk storage part of my desktop for the last 7 years, in a 3-drive RAID-Z configuration. I don't think any of the drives in the pool are the originals, as they have been swapped out for larger models as and when they started showing errors, with a scrub happening once a month. I have OS, swap, /home, /var, /tmp and ZFS log on an NVME drive separate - the ZFS pool is only used for the large stuff.
Separately, at work I managed to persuade them to configure our two new servers with ZFS, each with 168 drives for a total (after RAID) of 1.5PB each. Works like a charm, and is quite happy to saturate a 10Gb ethernet connection when accessing from another server, with transparent compression turned on. I would not hesitate to recommend ZFS to anyone.
Separately, at work I managed to persuade them to configure our two new servers with ZFS, each with 168 drives for a total (after RAID) of 1.5PB each. Works like a charm, and is quite happy to saturate a 10Gb ethernet connection when accessing from another server, with transparent compression turned on. I would not hesitate to recommend ZFS to anyone.